Lipid disorders among Black Africans non-users of lipid-lowering medication

ABSTRACT Objective: Angola is a sub-Saharan African country where the population has scarce access to lipidlowering medication. We sought to determine the frequency of lipid disorders among Angolan nonusers of lipid-lowering medication. Material and methods: A cross-sectional descriptive study was carried out in a sample of 604 workers from the public sector. Blood pressure and anthropometric data were measured along with biochemical parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). LDL-C to HDL-C ratio (LDL-C/HDL-C) was obtained from LDL-C and HDL-C levels. Results: High frequencies of elevated blood pressure (44.8%), metabolic syndrome (20.2%), increased TC (39.2%) and increased LDL-C (19.3%) were found. Low HDL-C was more frequent in women (62.4% vs. 36.1%, p < 0.001). Isolated hypercholesterolemia was more frequent in men (9.6% vs. 2.5%, p < 0.001). Among men TC, TG, LDL-C and LDL-C/HDL-C ratio were higher and HDL-C was lower in obese than in low-weight and normal-weight participants. Among women TC, TG, LDL-C and LDL-C/HDL-C ratio were higher in obese than in normal-weight participants. Significant linear trend of increasing TC and LDL-C levels as age increased was detected for both genders (p for trend < 0.05). Conclusion: The results of our study showed a high frequency of lipid disorders in Angolan non-users of lipid-lowering medication.

Association of nonalcoholic fatty liver disease with insulin resistance and dyslipidemia in patients with type 2 diabetes mellitus / 中华内分泌代谢杂志

ObjectiveTo investigate the association of nonalcoholic fatty liver disease (NAFLD) with insulin resistance and dyslipidemia in patients with type 2 diabetes mellitus,and to analyze the risk factors.Methods A total of 200 patients with type 2 diabetes mellitus including 99 with NAFLD and 101 without NAFLD were recruited.Height,weight,waist circumference,hip circumference,liver enzymes,blood lipids,fasting and postprandial blood glucose,insulin,C-peptide,and HbA1C levels were detected.Body mass index ( BMI),waist-hip ratio( WHR),and improved insulin and C-peptide index(HOMA-C-peptide) were calculated and compared between two groups.ResultsCompared with non-NAFLD group,weight,BMI,waist circumference,hip circumference,alanine aminotransferase ( ALT),aspartate aminotransferase,triglyceride ( TG ),total cholesterol ( TC ),low density lipoprotein-cholesterol(LDL-C) were significantly higher in NAFLD group( all P＜0.01 ),while age,duration,and high density lipoprotein-cholesterol were lower( all P＜0.05 ).The incidence of combined hyperlipidemia,especially hypertriglyceridemia,was significantly higher in NAFLD group( P＜0.01 ).Fasting and postprandial 1 h blood glucose [ ( 2.07 ±0.36 vs 1.83 ±0.43 ) mmol/L,( 14.04 ± 3.96 vs 12.59 ± 3.90 ) mmol/L ],fasting and postprandial 1 h Cpeptide [ (2.79± 1.15 vs 2.08±1.29 ) ng/ml,( 1.33 ±0.45 vs 1.12±0.54) ng/ml ],HbA1C [ (2.09±0.33 vs 1.96±0.28) ％ ],and HOMA-C-peptide index were significantly increased in NAFLD group ( P ＜ 0.05 or P ＜ 0.01 ).Logistic analysis showed that TG,BMI,and ALT were the major risk factors of NAFLD in type 2 diabetes mellitus( P＜0.05 or P＜0.01 ).ConclusionTriglyceridemia,obesity,and raised ALT level were significantly associated with an increased risk of NAFLD in patients with type 2 diabetes mellitus.

Lipid disorders in patients with cerebral inchemic stroke

Background: Cerebral stroke is an issue of great interest in the community, particularly the elderly. One of these risk factors, the risk of Lipid disorders is of primary concern.\r\n', u'Objectives: Research on Lipid to contribute recommended disease prevention and treatment of cerebral inchemic stroke.\r\n', u'Subjects and method: 44 patients with cerebral stroke (28 males, 16 females, age: 30-86, everage: 61.5+ 13.5) medically treated in the Faculty-Department of Heart-Kidney-Joint-Endocrinology and Faculty -Department of Neurology, Army Hospital 103, from May 2003 to July 2004 were include in the study. RL identified lipid in patients with cerebral inchemic stroke with hypertension according: Test the nervous system, cardiovascular system, brain computed tomography scanner, blood pressure monitoring, monitoring of dyslipidemia.\r\n', u'Results:The results obtained are as follows. The rate of lipid disorders among patients with is chemic cerebral stroke was 79.6%. The rates of lipid disorders closely increased with age, the older age the higher rate, and vice versa. The rate of lipid disorders in cerebralis ischemic stroke patients without arterial hypertension was 90.3%. In cerebral ischemic stroke patients without arterial hypertension, the rate of lipid disorders and non lipid disorders were about the same (53.9% vs 46.1%, respectively)\r\n', u'Conclusion: Research results entirely consistent with the theoretical basis and research. However, this problem should be studied further\r\n', u'\r\n', u'